You shur' do got a perty mouf!!!
I ended up riding alone a good portion of that route a couple years ago (look up the crush the commonwealth threads)...
Other than the ATA trail to Rockwood, and the Schuylkill River trail into Philly it is along roads and populated enough to not be scared like you should riding across West Virginia all alone
It is my experience that people are much friendlier out in the country than in the city. You will probably get more harassment from dogs along the route than people.