What specifically do you mean by check out?
I've always run my finger along the inside of the tire while making sure to look so that I don't cut my fingers on glass. That will usually find just about anything, given how sensitive your finger tips are.
Also, always line up the valve stem with the hot stamp on the tire (the brand label) with the label pointing to the drive side of the bike. That way, if you can't find the offending object you can inflate the tube, find the hole and match it up to where that hole would be on the tire.
I've almost never not found the source of a flat and am very hesitant to put a new tube in till I find what caused the flat.