You leave a lot of gaps in your description;
However, the Ghost Town trail would leave you in Ebensburg, PA which is in a reasonably hilly part of PA.
I would attempt to avoid old US 22, but rather ride backroads from Ebensburg to Loretto and back roads to PA53/Gallitzin and then descend via Horseshoe Curve Rd into Altoona and take backroads through Bellwood PA, Tyrone and old US220 all the way to Lock Haven and beyond to pick up the Pine Creek trail.
This would avoid "major" climbing.
I grew up in the Altoona-Ebensburg area and know the roads pretty well.