There is the "panhandle trail" from weirton wv to walkers mill...
www.panhandletrail.org/
Depending on how far south they are coming from...
you say 22, so I assume stuebenville....
Out of stuebenville you can take cove road off of 2
(2 is river road)... to The old stuebenville pike,
which is Old 22.
It is a nice wide road with a shoulder and lower traffic.
From there I would cut south to get to oakdale, like take kelso - north branch -978
I wouldnt take the old stuebenvill anywhere east of 978, it is ugly.... get down to oakdale and get on noblestown.... follow that basically all the way to the west end circle. there is some sprawl that there are shortcuts to avoid if he emails me i can tell him more
xsteevox at gmail